Book dossier

Intermediate filament cytoskeleton

by M. Bishr Omary, Pierre A. Coulombe

"Intermediate filaments, microfilaments and microtubules are the three major cytoskeletal protein families. Several features highlight intermediate filaments as reflected in part by their structure, mode of assembly, diversity, tissue selective expression, and association with a broad range of diseases including skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate Filament Cytoskeleton provides a comprehensive resource of methodology essentials for studying intermediate filaments in a broad range of organisms and biological contexts. It offers user-friendly advice and protocols covering all aspects of intermediate filament research including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Mammalian and non-mammalian systems, and animal models for human diseases are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. Book jacket."--Cover p. [4].